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Biosynthesis of (−)-indolactam V, the basic ring-structure of tumor promotes teleogidins

✍ Scribed by Kazuhiro Irie; Shin-ichiro Kajiyama; Atsushi Funaki; Koichi Koshimizu; Hideo Hayashi; Motoo Arai


Book ID
104226457
Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
269 KB
Volume
31
Category
Article
ISSN
0040-4039

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Synthesis and biological activities of n
✍ Kazuhiro Irie; Fumito Koizumi; Yoriko Iwata; Takashi Ishii; Yoshiaki Yanai; Yosh 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 361 KB

lndolactam-V (1) exists as two stable conformers, the twist and the sofa form, in solution at room temperature. 3-Aza-Cope rearrangement of (-)-N13-desmethyl-N13-allylindolactam-V (5) gave new conformationally restricted analogues (2a and 3) along with a normal rearrangement product (7). Both 2a and