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Synthesis and biological activities of fluorine-substituted (−)-indolactam-V, the core structure of tumor promoter teleocidins

✍ Scribed by Shigenori Okuno; Kazuhiro Irie; Yoko Suzuki; Koichi Koshimizu; Hoyoku Nishino; Akio Iwashima


Book ID
103982785
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
370 KB
Volume
4
Category
Article
ISSN
0960-894X

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lndolactam-V (1) exists as two stable conformers, the twist and the sofa form, in solution at room temperature. 3-Aza-Cope rearrangement of (-)-N13-desmethyl-N13-allylindolactam-V (5) gave new conformationally restricted analogues (2a and 3) along with a normal rearrangement product (7). Both 2a and