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Biosynthesis of aristeromycln: Evidence for the intermediacy of a 4β-hydroxymethyl-1α, 2α, 3α-trihydroxycyclopentanetriol.

✍ Scribed by Ronald J. Parry; Kochat Haridas; Randall De Jong; Carl R. Johnson

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
238 KB
Volume
31
Category
Article
ISSN
0040-4039

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✦ Synopsis

Evidence for the intermediacy of a 46-hydroxymethyl-1 a, 2a, 3a+ihydroxycyclopentanetriol (5 or 6) in the biosynthesis of the nucleoside antibiotic aristeromycin (1) has been obtained by administration of doubly-labeled forms of D-glucose to the fermentation broth of Strepfomyces citricolorfollowed by trapping of the tetrol 5 using isotope dilution methods.

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