Biosynthesis and processing of cathepsin K in cultured human osteoclasts
β Scribed by D.J Rieman; H.A McClung; R.A Dodds; S.M Hwang; M.W.LarkS Holmes; I.E James; F.H Drake; M Gowen
- Book ID
- 117807098
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 572 KB
- Volume
- 28
- Category
- Article
- ISSN
- 8756-3282
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## Abstract We report the effects of specific and potent inhibitors of vacularβtype H^+^βATPase and lysosomal cysteine proteinases, cathepsins, on the ultrastructure, expression of these enzymes, and resorptive functions of cultured osteoclasts. Osteoclasts were formed by coβculture of marrow cells
## Abstract Inhibitors of Cathepsin K (CatβK) are recognized as an interesting way to inhibit osteoclast (OC) activity. OCs from patients treated with the anticathepsinβK inhibitor AAE581 (balicatib) were found enlarged. They contained numerous vacuoles filled with tartrate resistant acid phosphata