Biosynthesis and chemical synthesis of carboxyl-linked glucuronide of lithocholic acid
✍ Scribed by Irma Panfil; Paul A. Lehman; Piotr Zimniak; Beat Ernst; Thomas Franz; Roger Lester; Anna Radominska
- Book ID
- 115741012
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 503 KB
- Volume
- 1126
- Category
- Article
- ISSN
- 0005-2760
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## Abstract A convenient synthesis is reported of lithocholic acid labelled in high isotopic purity with two atoms of deuterium at C‐11. Incorporation of deuterium is achieved by base‐catalyzed equilibration of a 12‐oxo bile acid in heavy water. The product is converted __in situ__ into its tosylhy
## Abstract Various mesogenic lithocholic acid (LA) derivatives [3‐acetyl LA (LAAC); 3‐propionyl LA (LAP), 3‐cinnamoyl LA (LACin); 3‐benzoyl LA (LAB), 3‐(4‐nitrobenzoyl) LA (LANB); and methyl‐3‐(3‐carboxypropionyl) LA, i.e., LA methyl ester monosuccinate (LAMeMS)] were reacted with hydroxyethyl cel