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Biosynthesis and characterization of [15N]actinomycin D and conformational analysis by nitrogen-15 nuclear magnetic resonance

✍ Scribed by Shafer, Richard H.; Formica, Joseph V.; Delfini, Claudio; Brown, Stephen C.; Mirau, Peter A.

Book ID
127149203
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
970 KB
Volume
21
Category
Article
ISSN
0006-2960

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Actinomycin D (ACD), Figure 1, is the most important member of a family of naturally occurring actinomycine whose primary biological function is the inhibition of DNA dependent RNA synthesis (5). If mechanisms propoaed for the biological activity of ACD ( 6) are to have a plausible structural basis,