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Bioresorbable Hydrogels Prepared Through Stereocomplexation between Poly(L-lactide) and Poly(D-lactide) Blocks Attached to Poly(ethylene glycol)

✍ Scribed by Suming Li

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
129 KB
Volume
3
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Block copolymers were synthesized by ring‐opening polymerization of L‐lactide or D‐lactide in the presence of mono‐ or dihydroxyl poly(ethylene glycol), using zinc metal as catalyst. The resulting copolymers were characterized by various techniques, namely ^1^H NMR spectroscopy, differential scanning calorimetry (DSC), X‐ray diffractometry, and Raman spectrometry. The composition of the copolymers was designed such that they were water soluble. Bioresorbable hydrogels were prepared from aqueous solutions containing both poly(L‐lactide)/poly(ethylene glycol) and poly(D‐lactide)/poly(ethylene glycol) block copolymers. Rheological studies confirmed the formation of hydrogels resulting from stereocomplexation between poly(L‐lactide) and poly(D‐lactide) blocks.

Ring‐opening polymerization of L(D)‐lactide in the presence of dihydroxyl PEG using zinc powder as catalyst.

magnified imageRing‐opening polymerization of L(D)‐lactide in the presence of dihydroxyl PEG using zinc powder as catalyst.

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