Suppression of Cell and Platelet Adhesion to Star-Shaped 8-Armed Poly(ethylene glycol)-Poly(L-lactide) Block Copolymer Films
✍ Scribed by Koji Nagahama; Yuichi Ohya; Tatsuro Ouchi
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 244 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
Summary: To explore the potential of a star‐shaped 8‐armed poly(ethylene glycol)35K‐block‐poly(L‐lactide)37K (8‐armed PEG35K‐b‐PLLA37K: $\overline M _{\rm n}$ of PEG = 35 000, $\overline M _{\rm n}$ of PLLA = 37 000) film as a novel bioabsorbable adhesion‐prevention membrane, the water structure, surface contact angle, protein adsorption, and cell and platelet anti‐adhesion properties of such a hydrated film are investigated. Based on the results, it is found that the 8‐armed PEG35K‐b‐PLLA37K film exhibits a biologically inert surface, which is the result of a large number of PEG chains and a free water layer on the film surface. This leads to a reduction in protein absorption and cell and platelet adhesion onto the film surface. This implies that the star‐shaped 8‐armed PEG35K‐b‐PLLA37K film can be utilized as a novel bioabsorbable adhesion‐prevention membrane.
A schematic presentation of the protein adsorption, platelet adhesion, and cell attachment phenomena for the 8‐armed PEG‐b‐PLLA films.
magnified imageA schematic presentation of the protein adsorption, platelet adhesion, and cell attachment phenomena for the 8‐armed PEG‐b‐PLLA films.