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Bioreduction of fluoroacetophenones by the fungi Aspergillus terreus and Rhizopus oryzae

✍ Scribed by João V. Comasseto; Álvaro T. Omori; Leandro H. Andrade; André L.M. Porto

Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 186 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00096-x

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✦ Synopsis

The enantioselective bioreduction of a number of fluoroacetophenones was carried out with whole cells of Rhizopus oryzae CCT 4964, Aspergillus terreus CCT 3320 and Aspergillus terreus CCT 4083 giving the corresponding alcohols in good yield and high enantioselectivity. Initial results with these fungi indicated that some of them are promising biocatalysts for deracemization reactions of secondary alcohols.

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