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Bioreactor design for cornea tissue engineering: Material–cell interactions

✍ Scribed by Elizabeth Orwin; Ajay Shah; Andrew Voorhees; Vilupanur Ravi

Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
835 KB
Volume
3
Category
Article
ISSN
1742-7061

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✦ Synopsis

Several materials were evaluated for potential use in a bioreactor system for a tissue-engineered cornea. Two types of cytotoxicity tests were performed using human corneal stromal fibroblasts: a 24 h cytotoxicity test based on the ASTM standard F813-01 and a 7 days growth inhibition test. It was determined that culture configuration, autoclaving and materials surface preparation were all important factors influencing cell viability. Poly(etheretherketone) and titanium-6Al-4V were found to be the most appropriate materials for use in a corneal bioreactor system. Furthermore, poly(oxymethylene) copolymer and poly(tetrafluoroethlylene) are not safe for use with human corneal fibroblasts after autoclaving.

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