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Biophysics of DNA–ligand interactions resolved by force: Comment on “Biophysical characterization of DNA binding from single molecule force measurements” by K.R. Chaurasiya et al.

✍ Scribed by Erwin J.G. Peterman; Peter Gross

Book ID: 108246220
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 75 KB
Volume: 7
Category: Article
ISSN: 1571-0645
DOI: 10.1016/j.plrev.2010.06.005

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This work is a valuable review of experiments that probe the interactions of small molecules and DNA under tension. However, I disagree with the review's premise (Sections 1.3 and 2.1) that overstretching of bare, torsionally unconstrained DNA consists solely of dehybridization of the molecule. Und