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‘Biomimetic’ oxidative dimerization of korupensamine A: Completion of the first total synthesis of michellamines A, B, and C

✍ Scribed by Gerhard Bringmann; Sven Harmsen; Jörg Holenz; Torsten Geuder; Roland Götz; Paul A. Keller; Rainer Walter; Yali F. Hallock; John H. Cardellina II; Michael R. Boyd

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
358 KB
Volume
50
Category
Article
ISSN
0040-4020

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✦ Synopsis

A first synthetic access to michellamine A (l), a C2-symmebic antiviral naturally occoning quatolaryl. is dcscriw hy oxidative 'dimcrization' of an appropriately protected 'monolnai~ naphthylisoquhmline alkaloid, aamcd lioruparpamine A (2). Duo to then synthe-tic aklabilii of 2 xecently achieved and given UE published iotexzoavcrsion of michellamii A -C. thii coupling reaction simoltaneously rqneaeots the completion of a fust total synthesis of a representative and thus of all hithextoknowamichellamines.

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