𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Biology and pathology of nonmyelinating Schwann cells

✍ Scribed by John W. Griffin; Wesley J. Thompson

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
324 KB
Volume
56
Category
Article
ISSN
0894-1491

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✦ Synopsis

Abstract

The CNS contains relatively few unmyelinated nerve fibers, and thus benefits from the advantages that are conferred by myelination, including faster conduction velocities, lower energy consumption for impulse transmission, and greater stability of point‐to‐point connectivity. In the PNS many fibers or regions of fibers the Schwann do not form myelin. Examples include C fibers nociceptors, postganglionic sympathetic fibers, and the Schwann cells associated with motor nerve terminals at neuromuscular junctions. These examples retain a degree of plasticity and a capacity to sprout collaterally that is unusual in myelinated fibers. Nonmyelin‐forming Schwann cells, including those associated with uninjured fibers, have the capacity to act as the “first responders” to injury or disease in their neighborhoods. © 2008 Wiley‐Liss, Inc.

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