Biologically Active Linear Metabolites of Arachidonic Acid—The First Endogenous Ligand of the Cannabinoid Receptor

Total synthesis of biologically active m

Total synthesis of biologically active metabolites of arachidonic acid. The two 8-hydroxy-11,12(S,S)-epoxyeicosa-5,14(Z),9(E)-trienoic acids.

✍ E.J. Corey; Wei-guo Su 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 229 KB

An efficient and simple total synthesis of the two C(8) diastereomers of 2, of interest as possible hormonal releasing agents, is described. A previous publication from this laboratory has described the synthesis of the two diastereomeric lo-hydroxy-11, lZ(S, S)-epoxyeicosa-5,9,14(Z)-trienoic acids