Biological significance of perineural invasion (PNI) in prostate cancer
✍ Scribed by Gaëlle Fromont; Julie Godet; Christophe Pires; Mokrane Yacoub; Bertrand Dore; Jacques Irani
- Book ID
- 112179536
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 158 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0270-4137
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## Abstract Men with clinically localized prostate cancer are faced with a wide range of treatment options, and only Gleason grading is universally used as a histopathological prognostic factor for this disease. The significance of perineural invasion in diagnostic biopsies is controversial. Opinio
## Abstract Metastasizing prostate tumor cells invade along nerves innervating the encapsulated human prostate gland in a process known as perineural invasion. The extacellular matrix laminin class of proteins line the neural route and tumor cells escaping from the gland express the laminin binding