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Biological properties of Phe°-opioid peptide analogues

✍ Scribed by Andrzej W. Lipkowski; Aleksandra Misicka; Keiko Hosohata; Peg Davis; Henry I. Yamamura; Frank Porreca; Victor J. Hruby


Book ID
117172743
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
35 KB
Volume
68
Category
Article
ISSN
0024-3205

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CD studies on tetrazole analogues of opioid peptides show that peptides sharing the same N-terminal sequence, H-TyrPsi[CN(4)]Gly-, give very large Cotton effects of the Tyr side chain in the near-UV region. CD spectra of five such peptides: H-TyrPsi[CN(4)]Gly-Gly-Phe-Leu-OH (I), H-TyrPsi[CN(4)]Gly-P