𝔖 Bobbio Scriptorium
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Biological properties and mode of action of clavams

✍ Scribed by F. Röhl; J. Rabenhorst; H. Zähner

Publisher
Springer
Year
1987
Tongue
English
Weight
585 KB
Volume
147
Category
Article
ISSN
0302-8933

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✦ Synopsis

The clavams valclavam and hydroxyethylclavam were both bacteriostatic and fungistatic. The molecular basis for growth inhibition of Escherichia coli was a non-competitive inhibition of homoserine-O-succinyltransferase (EC 2.3.1.46), thus blocking methionine biosynthesis. Eucaryotes such as Saccharomyces cerevisiae were inhibited by a different mode of action. Instead of interfering with methionine biosynthesis, the clavams inhibited the formation of RNA in living cells, although the RNA-polymerases of isolated yeast nuclei were not inhibited. The action of valclavam on E. coli was dependent on functional peptide transport systems.

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