Biological Membrane Ion Channels: Dynamics, Structure, and Applications

✍ Scribed by Peter C. Jordan (auth.), Shin-Ho Chung, Olaf S. Andersen, Vikram Krishnamurthy (eds.)

• Publisher: Springer-Verlag New York
• Year: 2007
• Tongue: English
• Leaves: 656
• Series: Biological And Medical Physics Biomedical Engineering
• Edition: 1
• Category: Library

✦ Synopsis

Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
Key Features
Presents the latest information on the molecular mechanisms of ion permeation through membrane ion channels
Uses schematic diagrams to illustrate important concepts in biophysics
Written by leading researchers in the area of ion channel investigations

✦ Table of Contents

Front Matter....Pages I-XIV
Ion Channels, from Fantasy to Fact in Fifty Years 1 ....Pages 3-29
Front Matter....Pages I-XIV
Gramicidin Channels: Versatile Tools....Pages 33-80
Voltage-Gated Ion Channels....Pages 81-118
Voltage-Gated Potassium Channels....Pages 119-170
BK Ca -Channel Structure and Function....Pages 171-218
Voltage-Gated Sodium Channels....Pages 219-239
Calcium Channels....Pages 241-299
Chloride Transporting CLC Proteins 1 ....Pages 301-333
Ligand-Gated Ion Channels: Permeation and Activation 1 ....Pages 335-367
Mechanosensitive Channels....Pages 369-398
TRP Channels....Pages 399-423
Ion Channels in Epithelial Cells....Pages 425-445
Front Matter....Pages I-XIV
Poisson–Nernst–Planck Theory of Ion Permeation Through Biological Channels....Pages 449-484
A Mesoscopic–Microscopic Perspective on Ion Channel Permeation Energetics: The Semi-Microscopic Approach 1 ....Pages 485-505
Brownian Dynamics: Simulation for Ion Channel Permeation 1 ....Pages 507-543
Molecular Dynamics Simulation Approaches to K Channels....Pages 545-567
Front Matter....Pages I-XIV
Patch-Clamp Technologies for Ion Channel Research....Pages 571-593
Gated Ion Channel-Based Biosensor Device....Pages 595-621
Signal Processing Based on Hidden Markov Models for Extracting Small Channel Currents....Pages 623-650

✦ Subjects

Biophysics/Biomedical Physics;Neurosciences;Biomedical Engineering;Neurobiology;Biotechnology;Animal Biochemistry