𝔖 Bobbio Scriptorium
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Biological activity of anti-thyrotropin anti-idiotypic antibody

✍ Scribed by M. N. Islam; Barbara M. Pepper; Rosario Briones-Urbina; Nadir R. Farid

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
854 KB
Volume
13
Category
Article
ISSN
0014-2980

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✦ Synopsis

Rabbit anti-rat anti-human thyrotropin anti-idiotypic antibodies have been raised. These antibodies were active at the thyrotropin (TSH) receptor, in that they inhibited 125I-labeled bovine TSH binding to thyroid plasma membranes, stimulated adenylate cyclase activity through a guanyl nucleotide-dependent mechanism, augmented radioiodide transport into isolated porcine thyroid follicular cells and induced such cultured cells to organize into follicles. Aside from substantiating the expectation that anti-hormone anti-idiotypic antibodies may possess properties of the original hormone, this work raised the possibility that thyroid-stimulating antibodies which cause the hyperthyroidism of Graves' disease may be anti-TSH anti-idiotypic antibodies.

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