An anti-carcinoembryonic antigen (CEA) antibody, NP-4, was labeled with 90Y using p-isothiocyanatobenzyl DTPA (SCN-Bz-DTPA) and its derivatives 1-(p-isothiocyanatobenzyl)-3-methyl-DTPA (1B3M), 2-(p-isothiocyanatobenzyl)-4-methyl-DTPA (1M3B), 1-(2)-methyl-4- isothiocyanatobenzyl-DTPA (MX-DTPA) as the
✦ LIBER ✦
Biokinetics of yttrium-90–labeled huBrE-3 monoclonal antibody
✍ Scribed by Timothy K. Johnson; William Cole; Robert A. Quaife; James L. Lear; Roberto L. Ceriani; Roy B. Jones; Pablo J. Cagnoni
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 204 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0008-543X
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## Abstract We have examined the application of ^90^Y‐DOTA‐cPAM4, anti‐MUC1 IgG, in combination with the front‐line drug gemcitabine as a potential therapeutic for pancreatic cancer. Athymic nude mice bearing CaPan1 human pancreatic cancer xenografts were administered 2 mg of gemcitabine on days 0,