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Advantage of yttrium-90-labeled over iodine-131-labeled monoclonal antibodies in the treatment of a human lung carcinoma xenograft

✍ Scribed by Rhona Stein; Susan Chen; Sara Haim; David M. Goldenberg


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
129 KB
Volume
80
Category
Article
ISSN
0008-543X

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✦ Synopsis


BACKGROUND. The purpose of this investigation was to compare the therapeutic

Rhona Stein, Ph


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## Abstract We have examined the application of ^90^Y‐DOTA‐cPAM4, anti‐MUC1 IgG, in combination with the front‐line drug gemcitabine as a potential therapeutic for pancreatic cancer. Athymic nude mice bearing CaPan1 human pancreatic cancer xenografts were administered 2 mg of gemcitabine on days 0,