Although the method by which Nature constructs the complex polycyclic structures characteristic of strychnine (I) and related bases (including the curare alkaloid group e.g. C-fluorocurarine, IIlp2) has been the subject of detailed discussion, a,4 no synthesis
Biogenetic-type sysnthesis in the oxindole alkaloid series
β Scribed by E.E. van Tamelen; J.P. Yardley; M. Miyano
- Publisher
- Elsevier Science
- Year
- 1963
- Tongue
- French
- Weight
- 234 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
AS the number and variety of established indole alkaloid structures increase, it becomes more and more apparent that many of the structural types derive by varying modes of cyclization of natural intermediates in which certain reactive sites have been brought to specific oxidation levels b . In such
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## Abstrac-Oxidation of the non-phenolic aporphines nuciferine (1). dicentrine (3). ocopodine (4) and thalicarpine ( 7) by iodine affords the corresponding dehydroaporphines (2. 5. 6 and 8). In contrast. iodine oxidation of non-phenolic noraporphines proceeds all the way to the oxoaporphine stage:
A new alkaloid, epioxyzoanthamine 4, has been isolated from a marine zoanthid. Its structure and relative stereochemisUT were determined through the interpretation of NMR spectral data. This compound as well as norzoanthamine, showed an unusual deuterium exchange at the methylene C-I 1 after treatme