Biogenetic-like synthesis of d,1-hirsutene

✍ Scribed by Yasufumi Ohfune; Haruhisa Shirahama; Takeshi Matsumoto

• Publisher: Elsevier Science
• Year: 1976
• Tongue: French
• Weight: 123 KB
• Volume: 17
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)93841-3

✦ Synopsis

Hirsutene is a tricyclic sesquiterpene hydrocarbon isolated from Coriolus censors and its structure was determined as shown in formula 101 h . The biosynthetic pathway' to hirsutene* has been suggested to involve a sequence of rearrangements depicted in Scheme I. we now wish to describe a chemical synthesis of hirsutene along the proposed biosynthetic route, starting from the previously described 7-keto-13-norprotoilludane k3.