Bioequivalence of 2 sustained release preparation of isosorbide-5-mononitrate
β Scribed by J. Bron; J.H.G. Jonkman; V.W. Steinijans; E. Dileti
- Book ID
- 117628691
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 181 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0928-0987
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In 10 healthy male subjects the pharmacokinetics and haemodynamic effects of sustained-release isosorbide-5-mononitrate 60 mg (IS-5-MN) were studied after oral administration at two different times in the day (08.00 h and 20.00 h). Effects on blood pressure and heart rate after 3 min standing uprigh
Isosorbide 2,s-dinitrate and its pharmacologically active metabolites, isosorbide 2-nitrate and isosorbide 5-nitrate, in plasma accumulated to the predicted steady-state after five consecutive oral doses of sustained-release tablets containing 40 mg isosorbide dinitrate at 12-h intervals and after f