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Biodegradations of statistical copolymers composed of D,L-lactide and cyclic carbonates

✍ Scribed by Chikara Tsutsumi; Katsuhiko Nakagawa; Hiroyuki Shirahama; Hajime Yasuda

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
270 KB
Volume
52
Category
Article
ISSN
0959-8103

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✦ Synopsis

Abstract

Syntheses and biodegradation of statistical copolymers of D,L‐lactide (D,L‐LA) with trimethylene carbonate (TMC), rac‐1‐methyltrimethylene carbonate (1‐MTMC) and 2,2‐dimethyltrimethylene carbonate (2,2‐DTMC) were investigated at various monomer ratios using SmMe(C~5~Me~5~)~2~THF as an initiator at 80 °C for 24 h in toluene. Biodegradations of poly(D,L‐LA‐co‐racemo‐1‐MTMC) (95/5) and poly(D,L‐LA‐co‐2,2‐DTMC) (98/2) with a compost at 60 °C proceed rapidly. Enzymatic degradations of these polymers were also performed using cholesterol esterase, lipoprotein lipase and proteinase K. Only poly(D,L‐LA‐co‐TMC) was biodegraded with cholesterol esterase, while poly(TMC), poly(1‐MTMC), poly(2,2‐DTMC) and poly(D,L‐LA) were barely degraded with these enzymes. Biodegradations of poly(D,L‐LA‐co‐TMC) (87/13) and poly(D,L‐LA‐co‐racemo‐1‐MTMC) (95/5) are rapid using proteinase K. Physical properties of these copolymers were also described.

© 2003 Society of Chemical Industry

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