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Biodegradation of a poly(?-amino acid) hydrogel. I.In vivo

✍ Scribed by Dickinson, H. R. ;Hiltner, A. ;Gibbons, D. F. ;Anderson, J. M.

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
679 KB
Volume
15
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

A new hydrogel material has been prepared by crosslinking a hydrophilic, nonionic poly(amino acid), poly(2‐hydroxyethyl‐L‐glutamine). The material properties of the hydrogel can be controlled by variation in the crosslink density, and the swelling ratio was found to be a sensitive and convenient method for measuring the extent of in vivo biodegradation of implanted specimens. Degradation of the material was observed only during the first 2 weeks of subcutaneous implantation in rats, and is attributed to hydrolysis by proteolytic enzymes released during the acute and chronic stages of the normal inflammatory response.

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