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Biodegradation of a poly-(?-amino acid) hydrogel. II.In vitro

✍ Scribed by Dickinson, Helen R. ;Hiltner, Anne

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
585 KB
Volume
15
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

Proteolytic enzymes have been employed in an in vitro model to simulate the in vivo degradation of a synthetic poly(amino acid) hydrogel. Trypsin and collagenase had no effect on crosslinked poly(2‐hydroxyethyl‐L‐glutamine) but pronase and papain dissolved the hydrogel. The initial effect of papain was to decrease the effective cross‐link density without producing soluble material. This effect was similar to that observed previously in vivo. Analysis of the papain digestion products showed that oligomers of degree of polymerization 4–9 were the chief products. The rate at which oligomers were formed increased with increasing crosslink density. This phenomenon was attributed to hydrophobic effects.

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