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Biodegradable sponges for hepatocyte transplantation

✍ Scribed by Mooney, D. J. ;Park, S. ;Kaufmann, P. M. ;Sano, K. ;McNamara, K. ;Vacanti, J. P. ;Langer, R.

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 738 KB
Volume: 29
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820290807

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✦ Synopsis

Liver cell transplantation may provide a means to replace lost or deficient liver tissue, but devices capable of delivering hepatocytes to a desirable anatomic location and guiding the development of a new tissue from these cells and the host tissue are needed. We have investigated whether sponges fabricated from poly-L-lactic acid (PLA) infiltrated with polyvinyl alcohol (PVA) would meet these requirements. Highly porous sponges (porosity = 9G95%) were fabricated from PLA using a particulate leaching technique. To enable even and efficient cell seeding, the devices were infiltrated with the hydrophilic polymer polyvinyl alcohol (PVA). This reduced their contact angle with water from 79

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