Biodegradable polymers as non-viral carriers for plasmid DNA delivery
โ Scribed by Jordy Luten; Cornelus F. van Nostrum; Stefaan C. De Smedt; Wim E. Hennink
- Book ID
- 113691672
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 979 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0168-3659
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๐ SIMILAR VOLUMES
## Abstract **Summary:** Since the first application of polymers as nonโviral gene delivery systems in 1965 by Vaheri and Pagano using functionalised dextran (A. Vaheri and J. S. Pagano, โInfectious poliovirus RNA: a sensitive method of assayโ, __Virology__ **1965**, __27__, 434โ6), a large number
## Abstract Poly(Lโsuccinimide)โ__graft__โpolyethylenimines (PSPs) were prepared as nonโviral vectors for gene transfection. Branched polyethylenimine ($\overline M \_{\rm w} $โ=โ800, PEI800) was grafted to poly(Lโsuccinimide) (PSI) in a oneโstep reaction with no catalyst. Gel retardation assay sho