✦ LIBER ✦

Biodegradable poly(lactic acid) polymers

✍ Scribed by Kulkarni, R. K. ;Moore, E. G. ;Hegyeli, A. F. ;Leonard, Fred

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 469 KB
Volume: 5
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820050305

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis of poly(lactic acids) from the cyclic lactides and properties of the polymers prepared have been described. Degradation rates in vitro under homogeous and heterogeneous conditions have been measured. The kinetics of deesterification under homogeneous conditions is second order and an activation energy of 11 Kcal/mol has been calculated. This is comparable to the value found for the hydrolysis of alkyl acetates. A biological in vitro method for determining the degradation of poly(lactic acids) has been described. The method indicates, in accordance with expectations, that poly(dl‐lactic acid) degrades at a faster rate than L(+) lactic acid. Initial results of medical evaluation of the polymers in suture, rod, and film form are presented.

📜 SIMILAR VOLUMES

Biodegradable polymer blends of poly(lac

Biodegradable polymer blends of poly(lactic acid) and poly(ethylene glycol)

✍ Mihir Sheth; R. Ananda Kumar; Vipul Davé; Richard A. Gross; Stephen P. McCarthy 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 524 KB

Poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG) were melt-blended and extruded into films in the PLA/PEG ratios of 100/0, 90/10, 70/30, 50/50, and 30/ 70. It was concluded from the differential scanning calorimetry and dynamic mechanical analysis results that PLA/PEG blends range from miscib

Synthesis and characterization of a nove

Synthesis and characterization of a novel biodegradable polymer poly(lactic acid–glycolic acid-4-hydroxyproline)

✍ Jiufang Duan; Jie Du; Yubin Zheng 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 251 KB 👁 2 views

Study on biodegradable polymer materials

Study on biodegradable polymer materials based on poly(lactic acid). I. Chain extending of low molecular weight poly(lactic acid) with methylenediphenyl diisocyanate

✍ Wei Zhong; Jinjie Ge; Zhenyu Gu; Wenjun Li; Xin Chen; Yi Zang; Yuliang Yang 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 163 KB 👁 2 views

Methylenediphenyl diisocyanate (MDI) was used as the chain extender for low molecular weight poly(lactic acid) (PLA) to produce high molecular weight biodegradable polymer material with a better heat resistance. PLA prepolymer with a number-average molecular weight (M n ) of 5800 and a weight-averag

Melt spinning of poly(L-lactic acid) and

Melt spinning of poly(L-lactic acid) and its biodegradability

✍ Yoshiro Nishimura; Akinori Takasu; Yoshihito Inai; Tadamichi Hirabayashi 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 2 views

Biodegradable Tablets Having a Matrix of

Biodegradable Tablets Having a Matrix of Low Molecular Weight poly-L-Lactic Acid and poly-D,L-Lactic Acid

✍ F. Moll; G. Köller 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 188 KB 👁 2 views

Synthesis and Characterization of Amphip

Synthesis and Characterization of Amphiphilic Biodegradable Copolymer, Poly(aspartic acid-co-lactic acid)

✍ Hosei Shinoda; Yukiko Asou; Akio Suetsugu; Kimiko Tanaka 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB

## Abstract An amphiphilic biodegradable polymer, poly(aspartic acid‐__co__‐lactic acid) (PAL), was synthesized by simply heating a mixture of aspartic acid (Asp) and L‐lactide without additional catalysts or solvents. The unique branched architecture comprising succinimide units and lactic acid un