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Biodegradable lactone copolymers. II. Hydrolytic study of ε-caprolactone and lactide copolymers

✍ Scribed by M. Malin; M. Hiljanen-Vainio; T. Karjalainen; J. Seppälä

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
784 KB
Volume
59
Category
Article
ISSN
0021-8995

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✦ Synopsis

Copolymers of c-CL/L-LA and c-CLIDL-LA were allowed to age in a buffer solution of pH 7 at 23 and 37°C. The effects of time and temperature on the rate of hydrolysis were examined by various techniques including weighing (water absorption and weight loss), SEC (molecular weight and polydispersity), and DSC (thermal properties). For comparison, the hydrolytic behavior of PLLA, PDLLA, and commercial PCL homopolymers was investigated by the same methods. SEC measurements showed that molecular weights of the copolymers and PLA homopolymers started to decrease during the first week of hydrolysis, but significant mass losses occurred only much later. As expected, there was no change in either molecular weight or mass of PCL during the hydrolysis study. The kinetic results for copolymers and homopolymers were calculated to study the degradation mechanism. During hydrolysis, the crystallinity of the initially semicrystalline copolymers increased and some crystallinity appeared in the initially amorphous L-LA-containing copolymers.

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