The biocompatibility of nine different materials, including positive and negative references, 4 polyurethane based and 3 latex based materials was investigated by (1) cytotoxic assay using V79 Chinese hamster cells, ( 2 ) the thickness of inflammatory layer at 3 and 7 days after intramuscular implan
Biocompatible materials for use in the vascular system
โ Scribed by Grode, Gerald A. ;Falb, Richard D. ;Crowley, James P.
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 267 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0021-9304
No coin nor oath required. For personal study only.
โฆ Synopsis
Techniques are presented which result in the production of thromboresistant materials Which can be used to interface with blood in the vascular system. Three useful processes for the heparinization of materials are presented and data are given on characteristics of attachment, the blood compatibility, and environmental stability of these surfaces. At this point, applications of heparinized surfaces via a simple one-step process should be limited to situations where low blood shear rates are involved, such as the venous system. Initial data indicate significant loss of surface heparin in situations where high blood flow rates are involved such as A-V shunts.
๐ SIMILAR VOLUMES
Relative sensitivity of in vitro biocompatibility test systems was explored. Cellular responses of 12 standardized cell lines to 20 materials representing a range of toxicity were measured. Each cell line and material combination was tested in duplicate using four different culture methods, and each
Scaffolds for tissue engineering should be biocompatible and stimulate rapid blood vessel ingrowth. Herein, we analyzed in vivo the biocompatibility and vascularization of three novel types of biodegradable porous polyurethane scaffolds. The polyurethane scaffolds, i.e., PU-S, PU-M and PU-F, were im
## Abstract Polytetrafluoroethylene surfaces have been treated to reduce thrombogenicity in order to make them suitable for use in prosthetic devices that come in contact with blood. This was done by first etching the surface with potassium in liquid ammonia to produce double bonds and then using t