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Biochemistry: The Role of the Iminium Bond in the Inhibition of Reverse Transcriptase by Quaternary Benzophenanthridines

โœ Scribed by MARK A. KERRY; OLIVIER DUVAL; ROGER D. WAIGH; SIMON P. MACKAY


Book ID
118111145
Publisher
Pharmaceutical Press
Year
1998
Tongue
English
Weight
774 KB
Volume
50
Category
Article
ISSN
2042-7158

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โœ Miriam Margalith; Haya Falk; Amos Panet ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› Springer ๐ŸŒ English โš– 439 KB

Three potential inhibitors of reverse transcriptase activities, phosphonoformate (PF), phosphonoacetate (PAA), and ethyl-diethyl phosphonoformate (Et-PF), were compared in this study. Only PF was found to inhibit the DNA polymerase activity of the purified reverse transcriptase of Moloney murine leu