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Biochemical Mechanism of Hepatitis C Virus Inhibition by the Broad-Spectrum Antiviral Arbidol†

✍ Scribed by Pécheur, Eve-Isabelle; Lavillette, Dimitri; Alcaras, Fanny; Molle, Jennifer; Boriskin, Yury S.; Roberts, Michael; Cosset, François-Loïc; Polyak, Stephen J.


Book ID
115439838
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
165 KB
Volume
46
Category
Article
ISSN
0006-2960

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Induction of heme oxygenase-1 (HO-1) inhibits hepatitis C virus (HCV) replication. Of the products of the reaction catalyzed by HO-1, iron has been shown to inhibit HCV ribonucleic acid (RNA) polymerase, but little is known about the antiviral activity of biliverdin (BV). Herein, we report that BV i