This study was undertaken to elucidate the mechanism@) of cross-resistance to cisplatin (CDDP) in a mitomycin C (MMC)resistant human bladder cancer cell line, J82/MMC. The J82/ MMC cell line displayed 2-to 3-fold cross-resistance to CDDP and carboplatin when compared to the parental )82/WT cells. Dr
Biochemical mechanism of cross-resistance to paclitaxel in a mitomycin c-resistant human bladder cancer cell line
โ Scribed by Richard J Bleicher; Hong Xia; Howard A Zaren; Shivendra V Singh
- Book ID
- 117469719
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 161 KB
- Volume
- 150
- Category
- Article
- ISSN
- 0304-3835
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This study describes characteristics of a mitomycin C (MMC)resistant human bladder cancer cell line, )82/MMC-2, which was established by repeated in vitro exposures of a 6-fold MMC-resistant variant (J82lMMC) to 18 nM MMC. A 9.6-fold higher concentration of MMC was required to kill 50% of the )82/MM
This study describes characteristics of a human bladder cancer cell line J82/MMC that is 6-fold more resistant to mitomycin C (MMC) than the parental cells. The J82/MMC subline was isolated by repeated continuous exposures of the J82/WT cells to increasing concentrations of MMC. The J82/MMC cell lin