Biochemical genetics of rat esterases: Polymorphism, tissue expression, and linkage of four loci

✍ Scribed by James E. Womack

• Publisher: Springer
• Year: 1973
• Tongue: English
• Weight: 621 KB
• Volume: 9
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00485587

✦ Synopsis

Two alleles at each of four esterase loci in Rattus norvegicus are described with regard to tissue expression, electrophoretic characterization, and genetic linkage. A previously described dominant gene for prealbumin serum esterase is demonstrated to exist as two codominant alleles in the genetically determined absence of the characteristic albumin esterase. The allelic composition of 16 inbred strains for four esterase genes is provided, and the heretofore ambiguous nomenclature of rat esterase genetics is standardized. Linkage of Es-1, Es-2, and Es-3 is demonstrated. Es-2 and Es-3 are tightly linked in that no recombination has been observed in 55 offspring. The same offspring demonstrated 9% recombination between Es-1 and the other two loci.