Glutamate oxalate transaminase (GOT) genetics inMus musculus: Linkage, polymorphism, and phenotypes of theGot-2andGot-1loci
✍ Scribed by Robert J. DeLorenzo; Frank H. Ruddle
- Publisher
- Springer
- Year
- 1970
- Tongue
- English
- Weight
- 834 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0006-2928
No coin nor oath required. For personal study only.
✦ Synopsis
A comparison of electrophoretic patterns of F 1 and baekcross progeny of two inbred strains of mice has revealed a new autosomal variant of the mitochondrial form of GOT.
The loci controlling the production of the soluble and mitochondrial forms of GOT have been designated Got-1 and Got-2, respectively. The two alleles of the Got-2 locus have been designated Got-2 a and Got-2 b, which represent the slow-and fast-migrating electrophoretic forms. Twenty-seven inbred strains of mice have been classified for Got-2 a and Got-2 b. It has been demonstrated that the polymorphism of Got-2 is widely distributed in feral mice. Got-2 was shown to be linked to Es-1, and evidence is also presented for linkage between Got-2 and Es-2, Es-5, and oligosyndactyly (Os). The absence of linkage of Got-2 to seven other loci has also been demonstrated. GOT was expressed in vitro in cell lines derived from human and mouse tissues. B 259 260 DeLorenzo and Ruddle Protein ~-Amino acids ~ Keto acids c i , tam, ac,d etoglu