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Biochemical genetic analysis of pyrimidine biosynthesis in mammalian cells: III. Association of carbamyl phosphate synthetase, aspartate transcarbamylase, and dihydroorotase in mutants of cultured Chinese hamster cells

✍ Scribed by Jeffrey N. Davidson; Diane V. Carnright; David Patterson


Book ID
112558902
Publisher
Springer
Year
1979
Tongue
English
Weight
895 KB
Volume
5
Category
Article
ISSN
1572-9931

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Biochemical genetic analysis of pyrimidi
✍ Thomas D. Stamato; David Patterson πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 798 KB

## Abstract A mutant (A204) of Chinese hamster ovary cells (CHO‐K1), which is deficient in dihydroorotate (DHO) dehydrogenase (E.C. 1.3.3.1) activity, has been isolated by a replica plating procedure. The mutant does not show a requirement for exogenously added pyrimidines. Examination of intact ce