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Biochemical evidence that Patched is the Hedgehog receptor

✍ Scribed by Marigo, Valeria; Davey, Robert A.; Zuo, Yi; Cunningham, James M.; Tabin, Clifford J.


Book ID
109798395
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
971 KB
Volume
384
Category
Article
ISSN
0028-0836

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Genetic evidence that Sil is required fo
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## Abstract Summary: The __Sil__ gene encodes a cytosolic protein required for mouse embryonic midline and left/right axial development. Based on the phenotype of __Sil__ mutant embryos, we hypothesized that Sil may be required for the activity of Sonic Hedgehog (Shh), a secreted signaling molecule