Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly
β Scribed by Ming, Jeffrey; Kaupas, Michelle; Roessler, Erich; Brunner, Han; Golabi, Mahin; Tekin, Mustafa; Stratton, Robert; Sujansky, Eva; Bale, Sherri; Muenke, Maximilian
- Book ID
- 113043549
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 77 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0340-6717
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We have used the mouse developing tooth germ as a model system to explore the transmission of Sonic hedgehog (Shh) signal in the induction of Patched (Ptc). In the early developing molar tooth germ, Shh is expressed in the dental epithelium, and the transcripts of Shh downstream target genes Ptc and
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