Biochemical and physiological differentiation during morphogenesis. XIV. The nucleic acids of the developing cerebral cortex and liver of the fetal guinea pig

✍ Scribed by Flexner, Josefa B. ;Flexner, Louis B.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1951
• Tongue: English
• Weight: 770 KB
• Volume: 38
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030380102

✦ Synopsis

JOSEFA C. FLEXSER AND LOUIS B. FLEXNER'

l k p w t n i e n t of h'mbt'yology, Carnegie Irtstitntiori of li'aslkington, Baltimore

THREE FIGURES

The observations reported here were undertaken to test by chemical iriethods the relation between the concentration of pentose nucleic acid ( P N A ) and the rate of protein synthesis in fetal nerve cells and hepatic cells. Therc is now a grcat deal of evidence that rapidly growing cells and others that secrete large amounts of protein have an increased concentration of P N A in their cytoplasm (Brachet, '50; Casperssou, '50) ; this evidence has led to the view that YWA is intimately concerned in some unknown way with protein synthesis. IIyden ( '37)' using Caspersson's technique of ultraviolet microspectrophotometry, has reported that young anterior horn cells during the whole period of their embryonic developineiit contain cytoplasmic nucleotidcs in high concentration in correspondence with their rapid rate of protein synthesis. Bodian ('47) points out that the regenerating netirone starts to reconstitute its axon with little PN-4 in the perikaryon but that increasing quantities appear with niore active spnthesis of axoplasm. Amounts of PXA in cscess of that in the acltilt h a w been found in fetal (Caspersson, '50) and in This inrestig:itinii n:rs snpportcd hy a grant from the Ameviran Cancer Society reromniciiclcd 1)p the Committee on Growth of the National Research ('onncil and by a research grant from the Division of Research Grants