Biochemical and physiological differentiation during morphogenesis. XII. Compounds of phosphorus in the developing cerebral cortex and liver of the fetal guinea pig

✍ Scribed by Flexner, Louis B. ;Flexner, Josefa B.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1950
• Tongue: English
• Weight: 816 KB
• Volume: 36
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030360304

✦ Synopsis

FOUR FIGURES

Because phosphorus is a part of so many substances of metabolic importance, it has long been of interest in biochemical studies of growth and development. In dcveloping muscle, significant changes have been observed in the concentration of phosphate fractions believed to be associated with cellular activity. Bald%-in and Needham ( '33) reported that phosphocreatine is at its niasimuni concentration in the chick when muscular movemcnt begins and Horvath ( '45) described large increases in the acid soluble as well as the acid insoluble phosphorus of rat niizsclle chiring the first 30 clays of life. Most of the stiidies on brain and liver have been during postnatal development. Yannet and Darrow ( '38), in the cat, failed to find any change during postnatal growth i n the concentration of non-Iipoid phosphorus of the intracellular fluid of the liver and conchided that increase wit11 ageing in the concentration of phosphorns in the brain is chiefly due to the deposition of lipoid in myelin sheaths. Yizch the same results have been reported f o r the rat This investigation was supported hy a p a n t from the Bmerican Cancer