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Biochemical and pharmacological effects of toremifene metabolites

โœ Scribed by Lauri Kangas

Book ID
104888303
Publisher
Springer
Year
1990
Tongue
English
Weight
567 KB
Volume
27
Category
Article
ISSN
0344-5704

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Pharmacological and biochemical studies with three metabolites of nomifensine
โœ H. Kruse; I. Hoffmann; H. J. Gerhards; M. Leven; U. Schacht ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› Springer ๐ŸŒ English โš– 571 KB

Three major metabolites (M1, M2, M3) of nomifensine (8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenyl-isoquinoline) are formed by hydroxylation and methoxylation of the phenyl ring. They were compared with nomifensine 1. in various psychopharmacological tests in vivo, carried out in mice after oral or i