Biochemical and metabolic abnormalities in normal and osteoarthritic human articular cartilage
โ Scribed by Junnosuke Ryu; Dr. Benjamin V. Treadwell; Henry J. Mankin
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 815 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
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We have recently described a 550,000-dalton nomollagenous cartilage matrix glycoprotein (CMGP), with subunits of 130,000, which is present in hyaline cartilage and fibrocartilage. Biosynthetic studies indicated that CMGP was synthesized by short-term organ cultures of normal canine articular cartila
## Abstract ## Objective Articular cartilage vesicles (ACVs) are extracellular organelles found in normal articular cartilage. While they were initially defined by their ability to generate pathologic calcium crystals in cartilage of osteoarthritis (OA) patients, they can also alter the phenotype
Proteases have been postulated to account for the progressive disappearance of matrix proteoglycans in osteoarthritic (OA) cartilage. The digestion of endogenous proteoglycans by neutral proteases in human OA cartilage homogenates has been measured and compared with that of normal age-matched contro