## Abstract Both enantiomers of the six major kinds of __γ__‐lactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various __rac__‐__N__‐methyl‐4‐hydroxyalkanamides via Grignard reaction and the enantioselective acetylatio
Biocatalytic Synthesis of Optically Active Hydroxyesters via Lipase-Catalyzed Decarboxylative Aldol Reaction and Kinetic Resolution
✍ Scribed by Zhang, Wei-Wei; Wang, Na; Feng, Xing-Wen; Zhang, Yang; Yu, Xiao-Qi
- Book ID
- 121653742
- Publisher
- Springer-Verlag
- Year
- 2014
- Tongue
- English
- Weight
- 702 KB
- Volume
- 173
- Category
- Article
- ISSN
- 0273-2289
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
The lipase-catalyzed acetylation of a broad spectrum of configurations of the 2-hydroxy acids 1 were assigned by comparison of the gas-chromatographic data with that of racemic 2-hydroxy acids 1 to their 2-acetoxy acids 2 was shown to proceed with high enantioselectivity. Thus, the literature-known
2,3]-Wittig rearrangement of 1,1,2-tri¯uoroallylic ethers gave ®ve types of novel 4,4,5-tri¯uoroalk-1,5dien-3-ols. The rearrangement reaction gave the alcohols with perfect (E)\*-selection over the newly created ole®n bond for two substrates. Lipase-catalyzed optical resolution of 4,4,5-tri¯uoroalk-