Biocatalytic synthesis of hydroxylated natural products using aldolases and related enzymes
β Scribed by Wolf-Dieter Fessner; Virgil Helaine
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 222 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0958-1669
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The use of radical cyclisations allows direct access to a family of azaspiroeyclic ketones, including compounds having the azaspiro[4,4]nonane, and azaspiro[5S]undecane structures which are found in the alkaloids cephalotaxine and histrionicotoxin.
New synthetic routes to chiral polyhydrox lated aldehydes from lower terms employing 2-substituted thiazoles as homologating reagents are descrited. In all cases the thiazole ring serves as a convenient formyl group equivalent.