Biocatalytic resolution of 2-methyl-2-(aryl)alkyloxiranes using novel bacterial epoxide hydrolases

✍ Scribed by I. Osprian; W. Kroutil; M. Mischitz; K. Faber

• Book ID: 104360950
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 420 KB
• Volume: 8
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(96)00493-4

✦ Synopsis

Biocatalytic resolution of alkyl-and (arylalkyl)-oxiranes was accomplished by employing the epoxide hydrolase activity of lyophilized whole cells of seven bacterial strains belonging to the genera Rhodococcus, Mycobacterium and Nocardia. Whereas no suitable biocatalyst was found for 1-octene oxide, excellent selectivities were obtained with 2-methyl-2-substituted epoxides bearing an alkyl-or (aryl)alkyl side chain.