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Deracemization of (±)-cis-2,3-epoxyheptane via enantioconvergent biocatalytic hydrolysis using Nocardia EH1-epoxide hydrolase

✍ Scribed by Wolfgang Kroutil; Martin Mischitz; Peter Plachota; Kurt Faber


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
199 KB
Volume
37
Category
Article
ISSN
0040-4039

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Deracemization of (±)-2,2-disubstituted
✍ Romano V.A. Orru; Wolfgang Kroutil; Kurt Faber 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 132 KB

2-Substituted (S)-1,2-diols were prepared in a one-pot procedure with >90% ee and >90% isolated yield via deracemization of (:l:)-2,2-disubstituted oxiranes through sequential (i) biocatalytic asymmetric hydrolysis using Nocardia EH1 epoxide hydrolase and (ii) acid catalyzed hydrolysis of the remain