Biocatalytic kinetic resolution of hydroperoxy vinylsilanes by horseradish peroxidase (HRP) and lipases, a comparative study

✍ Scribed by Waldemar Adam; Cordula Mock-Knoblauch; Chantu R. Saha-Möller

• Book ID: 104361214
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 244 KB
• Volume: 8
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(97)00197-3

✦ Synopsis

The kinetic resolution of hydroperoxy vinylsilanes 1 has been investigated by the horseradish-peroxidase(HRP)-catalyzed reduction with guaiacol and by the acetylation with isopropenyl acetate in the presence of various lipases. The best results (ee values up to 89% at 48% conversion) were obtained for the lipase-catalyzed reactions.