Bioavailability of norethindrone in women and rabbits after administration of norethindrone acetate through the subcutaneous route

First-pass elimination of lidocaine in t

First-pass elimination of lidocaine in the rabbit after peroral and rectal route of administration

✍ W. A. Ritschel; H. Elconin; G. J. Alcorn; D. D. Denson 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 400 KB 👁 2 views

Lidocaine shows pronounced first-pass metabolism upon peroral administration in man (about 30 per cent peroral bioavailability). Since the rectal bioavailability is about 65 per cent in man it is assumed that some drug is directly absorbed into systemic circulation by-passing the liver. In rats pero